| |
Partial mastectomy
|
Quadrantectomy
|
|---|
|
Remifentanil
|
Non-remifentanil
|
P value
|
Remifentanil
|
Non-remifentanil
|
P value
|
|---|
|
n = 98
|
n = 133
| |
n = 56
|
n = 156
| |
|---|
|
Blood loss, ml
|
60 [30, 94]
|
90 [50, 165]
|
< 0.001
|
90 [30,163]
|
140 [74, 220]
|
0.001
|
|
Mean SBP, mmHg
|
98 ± 11
|
115 ± 14
|
< 0.001
|
100 ± 11
|
115 ± 14
| |
|
Mean MBP, mmHg
|
74 ± 9
|
86 ± 11
|
< 0.001
|
74 ± 9
|
86 ± 11
|
< 0.001
|
|
Mean HR, bpm
|
71 ± 12
|
79 ± 12
|
< 0.001
|
71 ± 11
|
80 ± 13
|
< 0.001
|
|
Anesthesia time, min
|
188 ± 38
|
206 ± 43
|
< 0.001
|
220 ± 47
|
238 ± 42
|
0.006
|
|
Operative time, min
|
138 [115, 163]
|
147 [126, 182]
|
< 0.001
|
167 [139, 190]
|
179 [150, 211]
|
0.056
|
|
Infusion volume, ml
|
1300 [962, 1500]
|
1500 [1200, 1800]
|
< 0.001
|
1500 [1088, 1863]
|
177 [1300, 2000]
|
0.031
|
|
Re-operation for bleeding, n (%)
|
0/98 (0)
|
1/133 (0.8)
|
1
|
0/56 (0)
|
1/ 156 (0.6)
|
1
|
|
Intraoperative drug using, n (%)
|
|
Ephedrine
|
40/98 (41)
|
22/133 (17)
|
< 0.001
|
17/56 (30)
|
21/156 (13.5)
|
0.008
|
|
Phenylephrine
|
1/98 (1.0)
|
0/133 (0)
|
0.42
|
0/56 (0)
|
1/156 (0.6)
|
1
|
|
Atropine
|
41/98 (42)
|
11/133 (8.3)
|
< 0.001
|
21/56 (38)
|
34/156 (22)
|
0.032
|
|
Fentanyl
|
1/98 (1.0)
|
2/133 (1.5)
|
1
|
2/56 (3.6)
|
2/156 (1.3)
|
0.29
|
|
Pentazocine
|
0/98 (0)
|
4/133 (3.0)
|
0.14
|
0/56 (0)
|
2/156 (1.3)
|
1
|
|
Flurbiprofen axetil
|
59/98 (60)
|
52/133 (39)
|
0.002
|
38/56 (68)
|
42/156 (27)
|
< 0.001
|
|
Diclofenac suppository
|
5/98 (5.1)
|
7/133 (5.3)
|
1
|
4/56 (7.1)
|
30/156 (19)
|
0.035
|
|
Remifentanil infusion speed, mcg/kg/min
|
0.16 [0.11, 0.25]
| | |
0.21 [0.13, 0.29]
| | |
|
Inhaled anesthetics
|
|
Nitrous oxide–oxygen–sevoflurane*
|
3/98 (3.1)
|
107/133 (80)
|
< 0.001
|
1/56 (1.8)
|
138/156 (89)
|
< 0.001
|
- SBP intraoperative systolic blood pressure; MBP intraoperative mean blood pressure; HR intraoperative heart rate
- Continuous variables with normal distribution and with skewed distribution were expressed as mean ± SD and median [25%, 75%]. Categorical variable (ASA-PS) was expressed as number (%). Continuous variables were analyzed using Student’s t test or the Mann–Whitney U test as long as appropriate. Categorical variables were analyzed using Fisher exact test
- *One inhaled anesthetic other than nitrous oxide–oxygen–sevoflurane was oxygen–sevoflurane
