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Table 3 Showing GRADE ranking

From: The conundrum of guidelines, recommendations, and strength of recommendation

RecommendationWhat it implies?
HighConfident that the effect in the study reflects the actual effect.
ModerateQuite confident that the effect in the study is close to the true effect, but it is also possible it is substantially different.
LowTrue effect may differ significantly from the estimate.
Very lowTrue effect is likely to be substantially different from the estimated effect.