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Table 1 Comparison of various studies related to succinylcholine use in neonates

From: A systematic review and meta-analysis of the use of succinylcholine to facilitate tracheal intubation in neonates

Authors and year Study design N (patient number) Pre-medication drug Relaxant drug Comparison groups Successful attempt at intubation Time for successful intubation Duration of intubation Mean intra-procedure oxygen saturation (%) Mean HR Mean fall in PeTCO2 Incidence of bradycardia (B), kypotension (H), and cardiac arrest (C) MAP increase (time period for which SBP>20%) Intracranial hypertension Intubation related trauma
(Barrington et al., 1989) RCT 20
Preterm neonates
(A)- 10
(S)-10
(A) - Atropine
(S)-Atropine
(A)-None
(S)-Sch
(2mg/kg)
(A)- Atropine alone
(S)- Atropine with Sch
Not documented S- 53 ±26
A- 129±76
P value <0.0001
S 82±20 s
A 120±76
Hypoxia in none Mean HR Drop
(S) 169–153 ± 41
(A) 171–147 ±57
PETCO2 (A)
55± 23
(S) 86 ± 46TORR
(B), (H), and (C)-
None
(S) 41±23 s
(A) 46±89 s
ICP Rise to
(A)
41.4±
23.3cm
H 2O
(S)
36.8±11.6cm
H2O
 
(Ghanta et al., 2007) RCT 63
(P)-33
(S)-30
(P) group-
None
(S) group-
morphine, atropine
(P)-None
(S)-Succinyl-
Choline
(Sch)
, 2 mg/kg.
(P) -
Propofol
(S) -morphine, atropine, and Sch
group
Multiple attempts in
(S)-11/30
39%
(P)-18/33
57%1
(P) -120s
(S) -260s
  (P)-80% Sat
(S)-60% sat
Mean HR drop comparable 20 mmHg (P)
22 mmHg (S)
  No significant difference in all No sign difference observed   Seven infants on MASux (23%) and 2 infants on propofol (6%) sustained intubation-related trauma (P _ .117).
(Lemyre et al., 2009) Observational study 60
(S)-38
(C)- 22
Atropine
and fentanyl
(S)- Sch
(2mg/kg)
(C)-None
(S)-Sch
(C)-No Sch
Multiple
Attempts in-
(S)-15/38
42.1 %
(C)-17/22
81.8 %
Not documented   spO2 <80% in
(S)- 64.8%
(C)-85.7%
   No Significant difference in all    
(Oei et al., 2002) RCT 20
(PI)-10
(AI)-10
(PI)-Atropine, morphine
(AI)- None
(PI)- Sch
(1mg/kg)
(AI)- none
(PI)- Premedicated intubation
(AI)-Awake
intubation
Multiple attempts in
(PI)-10%
13 Attempts
(AI)-60%
31 attempts
(PI)- 60s
(AI)-595s
PI 174 ± 102 s Lowest sat
(PI)-
60 ± 20
(AI)-
58 ± 22
PI 28 ± 41
AI 62 ± 46
  (B)-more in (AI) group (p=0.040)
(H)- not documented
(C)- None
Max increase
AI
157 ± 24
PI
166 ± 13
  
(Venkatesh et al., 2011) Observational Study 93 Morphine, midazolam, atropine Sch
(2mg/kg)
Nil Multiple attempts in 43% 300s   39–85% Lowest recorded
94 (SCH) VS 120 (with ATR)
  (B)-46%
(H)- 30% as compared to baseline
(C)-none