Table 1 Comparison of various studies related to succinylcholine use in neonates
Authors and year | Study design | N (patient number) | Pre-medication drug | Relaxant drug | Comparison groups | Successful attempt at intubation | Time for successful intubation | Duration of intubation | Mean intra-procedure oxygen saturation (%) | Mean HR | Mean fall in PeTCO2 | Incidence of bradycardia (B), kypotension (H), and cardiac arrest (C) | MAP increase (time period for which SBP>20%) | Intracranial hypertension | Intubation related trauma |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
(Barrington et al., 1989) | RCT | 20 Preterm neonates (A)- 10 (S)-10 | (A) - Atropine (S)-Atropine | (A)-None (S)-Sch (2mg/kg) | (A)- Atropine alone (S)- Atropine with Sch | Not documented | S- 53 ±26 A- 129±76 P value <0.0001 | S 82±20 s A 120±76 | Hypoxia in none | Mean HR Drop (S) 169–153 ± 41 (A) 171–147 ±57 | PETCO2 (A) 55± 23 (S) 86 ± 46TORR | (B), (H), and (C)- None | (S) 41±23 s (A) 46±89 s | ICP Rise to (A) 41.4± 23.3cm H 2O (S) 36.8±11.6cm H2O | |
(Ghanta et al., 2007) | RCT | 63 (P)-33 (S)-30 | (P) group- None (S) group- morphine, atropine | (P)-None (S)-Succinyl- Choline (Sch) , 2 mg/kg. | (P) - Propofol (S) -morphine, atropine, and Sch group | Multiple attempts in (S)-11/30 39% (P)-18/33 57%1 | (P) -120s (S) -260s | (P)-80% Sat (S)-60% sat | Mean HR drop comparable 20 mmHg (P) 22 mmHg (S) | No significant difference in all | No sign difference observed | Seven infants on MASux (23%) and 2 infants on propofol (6%) sustained intubation-related trauma (P _ .117). | |||
(Lemyre et al., 2009) | Observational study | 60 (S)-38 (C)- 22 | Atropine and fentanyl | (S)- Sch (2mg/kg) (C)-None | (S)-Sch (C)-No Sch | Multiple Attempts in- (S)-15/38 42.1 % (C)-17/22 81.8 % | Not documented | spO2 <80% in (S)- 64.8% (C)-85.7% | No Significant difference in all | ||||||
(Oei et al., 2002) | RCT | 20 (PI)-10 (AI)-10 | (PI)-Atropine, morphine (AI)- None | (PI)- Sch (1mg/kg) (AI)- none | (PI)- Premedicated intubation (AI)-Awake intubation | Multiple attempts in (PI)-10% 13 Attempts (AI)-60% 31 attempts | (PI)- 60s (AI)-595s | PI 174 ± 102 s | Lowest sat (PI)- 60 ± 20 (AI)- 58 ± 22 | PI 28 ± 41 AI 62 ± 46 | (B)-more in (AI) group (p=0.040) (H)- not documented (C)- None | Max increase AI 157 ± 24 PI 166 ± 13 | |||
(Venkatesh et al., 2011) | Observational Study | 93 | Morphine, midazolam, atropine | Sch (2mg/kg) | Nil | Multiple attempts in 43% | 300s | 39–85% | Lowest recorded 94 (SCH) VS 120 (with ATR) | (B)-46% (H)- 30% as compared to baseline (C)-none |