Comparison between single-dose suxamethonium and rocuronium after pretreatment with dexmedetomidine in rapid sequence induction

Ain-Shams Journal of Anesthesiology

Table 5 Adverse effects between studied groups

Variable	Total number	SS group	DR group
Total number of patients with at least one adverse effect (%)	50/240 (21%)	36/120 (30%)	14/120 (11%)
Adverse effects:
1. Associated with pretreatment
• Nausea • Pain at the infusion site • Skin erythema • Total number of patients = n (%)	1 2 2 5/240 (2%)	0 0 0 0/120	1 2 2 5/120 (4%)
2. Associated with neuromuscular relaxant administration
• Hypotension • edema • Skin rash • bronchospasm • Total number of patients = n (%)	2 0 13 1 16/237 (7%)	0 0 10 1 11/119* (9%)	2 0 3 0 5/118† (4%)
3. At 24 h post-operative
• Operative Recall-awareness • Muscle ache • Total number of patients= n (%)	0 27 27/228 (11%)	0 24 24/113‡ (21%)	0 3 3/115§ (2%)

Abbreviations: N, number of patients; SS, saline (pretreatment) + suxamethonium; DR, dexmedetomidine (pretreatment) + rocuronium
*One patient withdrew from the study before administration of the neuromuscular blocking agent for no reason
^†Data from 6 patients were excluded due to protocol violation
^‡Two patients withdrew from the study due to pain at the infusion site
^§Three patients withdrew from the study due to protocol violation