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Table 3 PO sedation and pain data of patients of the four groups

From: Preoperative oral melatonin can reduce preoperative anxiety and postoperative analgesia in a dose-dependent manner

Variables Group
P M1 M2 Z
Score Score P1 Score P1 P2 Score P1 P2 P3
RSS
 30 min 1.7±0.6 2±0.6 0.018 2.1±0.8 0.008 0.498 2.4±0.6 0.001 0.007 0.095
 60 min 2.7±0.5 1.8±0.7 0.001 1.8±0.6 0.001 0.992 2±0.6 0.001 0.2 0.177
 90 min 1.5±0.5 2.6±0.5 0.001 1.66±0.8 0.201 0.0001 2±0.8 0.002 0.0005 0.078
 120 min 1.8±0.7 2.4±0.6 0.001 1.4±0.5 0.012 0.0001 1.5±0.5 0.08 0.0001 0.344
Number of patients who achieved Aldrete score permissible for PACU discharge (>8)
  Number Number P1 Number P1 P2 Number P1 P2 P3
 At <60 min 12 (34.3%) 20 (57.1%) 0.157 16 (45.7%) 0.479 0.476 13 (37.1%) 0.234 0.072 0.509
 At 60–120 min 18 (51.4%) 12 (34.3%) 13 (37.1%) 12 (34.3%)
 At >120 min 5 (14.3%) 3 (8.6%) 6 (17.2%) 10 (28.6%)
PO pain data
 No. of requests of analgesia 0 0 0 0.002 15 (42.9%) <0.001 0.0003 7 (20%) 0.0009 0.059 0.049
1 10 (28.6%) 27 (77.1%) 17 (48.5%) 19 (54.3%)
2 25 (71.4%) 8 (22.9%) 3 (8.6%) 9 (25.7%)
 Duration of PO analgesia 0.9±0.4 3.4±1.6 <0.001 5.2±2.2 <0.001 0.0012 2.9±1.9 <0.001 0.258 0.0005
 Cumulative 8-h NRS pain score 2.2±0.4 2.1±0.4 0.334 1.7±0.5 0.0002 0.019 2±0.6 0.0004 0.12 0.078
  1. Data are presented as mean±SD, numbers, and percentages. p <0.05 indicates significant difference; p>0.05 indicates non-significant difference
  2. P1 Significance of difference versus group P, P2 Significance of difference versus group M1, P3 Significance of difference versus group M2 according to one-way ANOVA test for parametric variables and Chi-square test with Yates correction for non-parametric numerical values