Preoperative oral melatonin can reduce preoperative anxiety and postoperative analgesia in a dose-dependent manner

Ain-Shams Journal of Anesthesiology

Table 3 PO sedation and pain data of patients of the four groups

Variables		Group
		P	M1		M2			Z
		Score	Score	P1	Score	P1	P2	Score	P1	P2	P3
RSS
30 min		1.7±0.6	2±0.6	0.018	2.1±0.8	0.008	0.498	2.4±0.6	0.001	0.007	0.095
60 min		2.7±0.5	1.8±0.7	0.001	1.8±0.6	0.001	0.992	2±0.6	0.001	0.2	0.177
90 min		1.5±0.5	2.6±0.5	0.001	1.66±0.8	0.201	0.0001	2±0.8	0.002	0.0005	0.078
120 min		1.8±0.7	2.4±0.6	0.001	1.4±0.5	0.012	0.0001	1.5±0.5	0.08	0.0001	0.344
Number of patients who achieved Aldrete score permissible for PACU discharge (>8)
		Number	Number	P1	Number	P1	P2	Number	P1	P2	P3
At <60 min		12 (34.3%)	20 (57.1%)	0.157	16 (45.7%)	0.479	0.476	13 (37.1%)	0.234	0.072	0.509
At 60–120 min		18 (51.4%)	12 (34.3%)		13 (37.1%)			12 (34.3%)
At >120 min		5 (14.3%)	3 (8.6%)		6 (17.2%)			10 (28.6%)
PO pain data
No. of requests of analgesia	0	0	0	0.002	15 (42.9%)	<0.001	0.0003	7 (20%)	0.0009	0.059	0.049
	1	10 (28.6%)	27 (77.1%)		17 (48.5%)			19 (54.3%)
	2	25 (71.4%)	8 (22.9%)		3 (8.6%)			9 (25.7%)
Duration of PO analgesia		0.9±0.4	3.4±1.6	<0.001	5.2±2.2	<0.001	0.0012	2.9±1.9	<0.001	0.258	0.0005
Cumulative 8-h NRS pain score		2.2±0.4	2.1±0.4	0.334	1.7±0.5	0.0002	0.019	2±0.6	0.0004	0.12	0.078

Data are presented as mean±SD, numbers, and percentages. p <0.05 indicates significant difference; p>0.05 indicates non-significant difference
P1 Significance of difference versus group P, P2 Significance of difference versus group M1, P3 Significance of difference versus group M2 according to one-way ANOVA test for parametric variables and Chi-square test with Yates correction for non-parametric numerical values