Table 1 Summary of studies on gastric cancer that compare TIVA with GA

(Huang et al. 2020)

Retrospective

TIVA vs GA (none of the patients had epidural catheter)

TIVA (n = 190)

Ind = propofol + fentanyl + lidocaine 2% + rocuronium

Man: propofol infusion + fentanyl (repetitive bolus) + cisatracurium (repetitive bolus)

GA (n = 218)

I = propofol + fentanyl + lidocaine + rocuronium or succinylcholine

M: desflurane + fentanyl (repetitive bolus) + cisatracurium (repetitive bolus)

TIVA improved survival and reduced the risk of recurrence and metastasis during the 5-year follow-up

(Hong et al. 2019)

Retrospective

TIVA vs GA (5 major types of surgery evaluated) (breast, colon, liver, lung, stomach)

TIVA (n = 903)

I = propofol + remifentanil

M: propofol infusion + remifentanil infusion

GA (n = 1304)

I = propofol/etomidate + remifentanil

M: remifentanil/N20 + (desflurane/sevoflurane/isoflurane)

There were no differences 5 years overall

(Oh et al. 2019)

Retrospective cohort

TIVA vs GA (none of the patients had epidural catheter)

TIVA (n = 769)

I = propofol + remifentanil

M: propofol infusion + remifentanil infusion

GA (n = 769)

I = remifentanil + (desflurane/sevoflurane)

M: remifentanil + (desflurane/sevoflurane)

Propofol-based TIVA was not significantly associated with decrease in the 1-year overall or cancer-related mortality

(Zheng et al. 2018)

Retrospective observational study

TIVA vs GA

TIVA (n = 897)

I = midazolam + propofol + fentanyl

M: propofol infusion + remifentanil infusion

Postoperative analgesia: IV PCA (fentanyl or sufentanil)

GA (n = 897)

I = midazolam + propofol + fentanyl

M = sevoflurane + remifentanil infusion

Postoperative analgesia: IV PCA (fentanyl or sufentanil)

TIVA may be associated with improved survival